The Binding of Isaac: Afterbirth+ (2017)

The Binding of Isaac: Afterbirth+ is a dungeon-crawling shoot-'em-up that's literally a different game each and every time you play it! The randomly generated maps are built with over 11,000 unique room configurations, each populated with a nearly endless variety of enemies, items, challenges and secrets!

Storyline

When Isaac's mother starts hearing the voice of God demanding a sacrifice be made to prove her faith, Isaac escapes into the basement facing droves of deranged enemies, lost brothers and sisters, his fears, and eventually his mother.